Neurological aspect of systemic lupus erythematosus.

Afteraoi Kaposi1) designated the condition characterized by fever, toxic mani festations and cutaneous lesions resembling those of erysipelas disseminatus as lupus erythematosus disseminatus 94 years ago and Osler2) first emphasized the significance of the systemic manifestations of the disease 71 years ago, Pale was first to make a systematic review of cerebral involvements and refered to the now well-known neurological signs of this disease-toxic psychosis, convulsion and scattered neurological findings. Peripheral neuritis, was first described in this disease by Hepteinstall.and. Sowry4) in 1952 and Malamud and Savers) in 1954 summarized neuropathological findings. Harvey et al.6) in a review of literature and analysis of their cases, and Clark7)-9) in a series of papers men tioned a variety of neurological signs and symptoms. Numerous case reports of SLE (systemic lupus erythematosus) with neurological signs and symptoms have also been made over the past ten years.